Brief Report: Dolutegravir Plus Abacavir/Lamivudine for the Treatment of HIV-1 Infection in Antiretroviral Therapy-Naive Patients: Week 96 and Week 144 Results From the SINGLE Randomized Clinical Trial
Identifieur interne : 000187 ( Main/Exploration ); précédent : 000186; suivant : 000188Brief Report: Dolutegravir Plus Abacavir/Lamivudine for the Treatment of HIV-1 Infection in Antiretroviral Therapy-Naive Patients: Week 96 and Week 144 Results From the SINGLE Randomized Clinical Trial
Auteurs : Sharon Walmsley [Canada] ; Axel Baumgarten [Allemagne] ; Juan Berenguer [Espagne] ; Franco Felizarta [États-Unis] ; Eric Florence [Belgique] ; Marie-Aude Khuong-Josses [France] ; J. Michael Kilby [États-Unis] ; Thomas Lutz [Allemagne] ; Daniel Podzamczer [Espagne] ; Joaquin Portilla [Espagne] ; Norman Roth [Australie] ; Deborah Wong [Royaume-Uni] ; Catherine Granier [Royaume-Uni] ; Brian Wynne ; Keith PappaSource :
- Journal of Acquired Immune Deficiency Syndromes (1999) [ 1525-4135 ] ; 2015.
Abstract
The SINGLE study was a randomized, double-blind, noninferiority study that evaluated the safety and efficacy of 50 mg dolutegravir + abacavir/lamivudine versus efavirenz/tenofovir/emtricitabine in 833 ART-naive HIV-1 + participants. Of 833 randomized participants, 71% in the dolutegravir + abacavir/lamivudine arm and 63% in the efavirenz/tenofovir/emtricitabine arm maintained viral loads of <50 copies per milliliter through W144 (
Url:
DOI: 10.1097/QAI.0000000000000790
PubMed: 26262777
PubMed Central: 4645960
Affiliations:
- Allemagne, Australie, Belgique, Canada, Espagne, France, Royaume-Uni, États-Unis
- Angleterre, Berlin, Californie, Caroline du Sud, Catalogne, Communauté de Madrid, Grand Londres
- Barcelone, Berlin, Londres, Madrid, Paris
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Week 144 Results From the SINGLE Randomized Clinical Trial</title><author><name sortKey="Walmsley, Sharon" sort="Walmsley, Sharon" uniqKey="Walmsley S" first="Sharon" last="Walmsley">Sharon Walmsley</name><affiliation wicri:level="1"><nlm:aff id="aff1">University Health Network, Toronto, ON, Canada;</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>University Health Network, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Baumgarten, Axel" sort="Baumgarten, Axel" uniqKey="Baumgarten A" first="Axel" last="Baumgarten">Axel Baumgarten</name><affiliation wicri:level="3"><nlm:aff id="aff2">MIB Infectious Diseases Medical Center, Berlin, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>MIB Infectious Diseases Medical Center, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Berenguer, Juan" sort="Berenguer, Juan" uniqKey="Berenguer J" first="Juan" last="Berenguer">Juan Berenguer</name><affiliation wicri:level="3"><nlm:aff id="aff3">Hospital General Universitario Gregorio Marañón, Madrid, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital General Universitario Gregorio Marañón, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Felizarta, Franco" sort="Felizarta, Franco" uniqKey="Felizarta F" first="Franco" last="Felizarta">Franco Felizarta</name><affiliation wicri:level="2"><nlm:aff id="aff4">Private practice, Bakersfield, CA;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Private practice, Bakersfield</wicri:cityArea></affiliation></author><author><name sortKey="Florence, Eric" sort="Florence, Eric" uniqKey="Florence E" first="Eric" last="Florence">Eric Florence</name><affiliation wicri:level="1"><nlm:aff id="aff5">Institute of Tropical Medicine, Antwerp, Belgium;</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Institute of Tropical Medicine, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Khuong Josses, Marie Aude" sort="Khuong Josses, Marie Aude" uniqKey="Khuong Josses M" first="Marie-Aude" last="Khuong-Josses">Marie-Aude Khuong-Josses</name><affiliation wicri:level="1"><nlm:aff id="aff6">Hôpital Delafontaine, Paris, France;</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Delafontaine, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kilby, J Michael" sort="Kilby, J Michael" uniqKey="Kilby J" first="J. Michael" last="Kilby">J. Michael Kilby</name><affiliation wicri:level="2"><nlm:aff id="aff7">Medical University of South Carolina, Charleston, SC;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Lutz, Thomas" sort="Lutz, Thomas" uniqKey="Lutz T" first="Thomas" last="Lutz">Thomas Lutz</name><affiliation wicri:level="1"><nlm:aff id="aff8">Infektiologikum Frankfurt, Frankfurt, Germany;</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Infektiologikum Frankfurt, Frankfurt</wicri:regionArea><wicri:noRegion>Frankfurt</wicri:noRegion><wicri:noRegion>Frankfurt</wicri:noRegion><wicri:noRegion>Frankfurt</wicri:noRegion></affiliation></author><author><name sortKey="Podzamczer, Daniel" sort="Podzamczer, Daniel" uniqKey="Podzamczer D" first="Daniel" last="Podzamczer">Daniel Podzamczer</name><affiliation wicri:level="3"><nlm:aff id="aff9">Hospital Universitari de Bellvitge, L'Hospitalet, Barcelona, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitari de Bellvitge, L'Hospitalet, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Portilla, Joaquin" sort="Portilla, Joaquin" uniqKey="Portilla J" first="Joaquin" last="Portilla">Joaquin Portilla</name><affiliation wicri:level="1"><nlm:aff id="aff10">Hospital General Universitario de Alicante, Alicante, Spain;</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital General Universitario de Alicante, Alicante</wicri:regionArea><wicri:noRegion>Alicante</wicri:noRegion></affiliation></author><author><name sortKey="Roth, Norman" sort="Roth, Norman" uniqKey="Roth N" first="Norman" last="Roth">Norman Roth</name><affiliation wicri:level="1"><nlm:aff id="aff11">Prahran Market Clinic, Melbourne, Australia;</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Prahran Market Clinic, Melbourne</wicri:regionArea><wicri:noRegion>Melbourne</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Deborah" sort="Wong, Deborah" uniqKey="Wong D" first="Deborah" last="Wong">Deborah Wong</name><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff12">GlaxoSmithKline, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GlaxoSmithKline, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Granier, Catherine" sort="Granier, Catherine" uniqKey="Granier C" first="Catherine" last="Granier">Catherine Granier</name><affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff12">GlaxoSmithKline, London, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>GlaxoSmithKline, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wynne, Brian" sort="Wynne, Brian" uniqKey="Wynne B" first="Brian" last="Wynne">Brian Wynne</name><affiliation><nlm:aff id="aff13">GlaxoSmithKline, Research Triangle Park, NC.</nlm:aff><wicri:noCountry code="subfield">NC.</wicri:noCountry></affiliation></author><author><name sortKey="Pappa, Keith" sort="Pappa, Keith" uniqKey="Pappa K" first="Keith" last="Pappa">Keith Pappa</name><affiliation><nlm:aff id="aff13">GlaxoSmithKline, Research Triangle Park, NC.</nlm:aff><wicri:noCountry code="subfield">NC.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Acquired Immune Deficiency Syndromes (1999)</title><idno type="ISSN">1525-4135</idno><idno type="eISSN">1944-7884</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract:</title><p>The SINGLE study was a randomized, double-blind, noninferiority study that evaluated the safety and efficacy of 50 mg dolutegravir + abacavir/lamivudine versus efavirenz/tenofovir/emtricitabine in 833 ART-naive HIV-1 + participants. Of 833 randomized participants, 71% in the dolutegravir + abacavir/lamivudine arm and 63% in the efavirenz/tenofovir/emtricitabine arm maintained viral loads of <50 copies per milliliter through W144 (<italic>P</italic> = 0.01). Superior efficacy was primarily driven by fewer discontinuations due to adverse events in the dolutegravir + abacavir/lamivudine arm [dolutegravir + abacavir/lamivudine arm, 13 (3%); efavirenz/tenofovir/emtricitabine arm, 48 (11%)] through W144. No treatment-emergent integrase or nucleoside resistance was observed in dolutegravir + abacavir/lamivudine recipients through W144.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Walmsley, Sl" uniqKey="Walmsley S">SL Walmsley</name></author><author><name sortKey="Antela, A" uniqKey="Antela A">A Antela</name></author><author><name sortKey="Clumeck, N" uniqKey="Clumeck N">N Clumeck</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Eron, Jj" uniqKey="Eron J">JJ Eron</name></author><author><name sortKey="Clotet, B" uniqKey="Clotet B">B Clotet</name></author><author><name sortKey="Durant, J" uniqKey="Durant J">J Durant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raffi, F" uniqKey="Raffi F">F Raffi</name></author><author><name sortKey="Rachlis, A" uniqKey="Rachlis A">A Rachlis</name></author><author><name sortKey="Stellbrink, Hj" uniqKey="Stellbrink H">HJ Stellbrink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stellbrink, Hj" uniqKey="Stellbrink H">HJ Stellbrink</name></author><author><name sortKey="Reynes, J" uniqKey="Reynes J">J Reynes</name></author><author><name sortKey="Lazzarin, A" uniqKey="Lazzarin A">A Lazzarin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Lunzen, J" uniqKey="Van Lunzen J">J van Lunzen</name></author><author><name sortKey="Maggiolo, F" uniqKey="Maggiolo F">F Maggiolo</name></author><author><name sortKey="Arribas, Jr" uniqKey="Arribas J">JR Arribas</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Berlin</li><li>Californie</li><li>Caroline du Sud</li><li>Catalogne</li><li>Communauté de Madrid</li><li>Grand Londres</li></region><settlement><li>Barcelone</li><li>Berlin</li><li>Londres</li><li>Madrid</li><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Pappa, Keith" sort="Pappa, Keith" uniqKey="Pappa K" first="Keith" last="Pappa">Keith Pappa</name><name sortKey="Wynne, Brian" sort="Wynne, Brian" uniqKey="Wynne B" first="Brian" last="Wynne">Brian Wynne</name></noCountry><country name="Canada"><noRegion><name sortKey="Walmsley, Sharon" sort="Walmsley, Sharon" uniqKey="Walmsley S" first="Sharon" last="Walmsley">Sharon Walmsley</name></noRegion></country><country name="Allemagne"><region name="Berlin"><name sortKey="Baumgarten, Axel" sort="Baumgarten, Axel" uniqKey="Baumgarten A" first="Axel" last="Baumgarten">Axel Baumgarten</name></region><name sortKey="Lutz, Thomas" sort="Lutz, Thomas" uniqKey="Lutz T" first="Thomas" last="Lutz">Thomas Lutz</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Berenguer, Juan" sort="Berenguer, Juan" uniqKey="Berenguer J" first="Juan" last="Berenguer">Juan Berenguer</name></region><name sortKey="Podzamczer, Daniel" sort="Podzamczer, Daniel" uniqKey="Podzamczer D" first="Daniel" last="Podzamczer">Daniel Podzamczer</name><name sortKey="Portilla, Joaquin" sort="Portilla, Joaquin" uniqKey="Portilla J" first="Joaquin" last="Portilla">Joaquin Portilla</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Felizarta, Franco" sort="Felizarta, Franco" uniqKey="Felizarta F" first="Franco" last="Felizarta">Franco Felizarta</name></region><name sortKey="Kilby, J Michael" sort="Kilby, J Michael" uniqKey="Kilby J" first="J. Michael" last="Kilby">J. Michael Kilby</name></country><country name="Belgique"><noRegion><name sortKey="Florence, Eric" sort="Florence, Eric" uniqKey="Florence E" first="Eric" last="Florence">Eric Florence</name></noRegion></country><country name="France"><noRegion><name sortKey="Khuong Josses, Marie Aude" sort="Khuong Josses, Marie Aude" uniqKey="Khuong Josses M" first="Marie-Aude" last="Khuong-Josses">Marie-Aude Khuong-Josses</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Roth, Norman" sort="Roth, Norman" uniqKey="Roth N" first="Norman" last="Roth">Norman Roth</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Wong, Deborah" sort="Wong, Deborah" uniqKey="Wong D" first="Deborah" last="Wong">Deborah Wong</name></region><name sortKey="Granier, Catherine" sort="Granier, Catherine" uniqKey="Granier C" first="Catherine" last="Granier">Catherine Granier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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